Tag: IGF-1

The Growth Hormone Jungle

April 29, 2018 By arne hendriks Off

Growth hormone is a peptide hormone that stimulates growth, cell reproduction and cell regeneration in humans and other animals. As with all hormonal pathways the path concerning the promotion and secretion of growth hormone leads right into a dense entanglement of interrelated secretions of life. If…

HPS Axis Pirouette

March 15, 2018 By arne hendriks Off

To soften the pressure of the increasingly dominant genetic profiles for greater human height, humanity at some point may opt to interfere in the cell signaling pathways that induce growth. One such pathway, the hypothalamic–pituitary axis, includes the secretion of growth hormone (GH) into the circulation and the subsequent stimulation of insulin-like…

Vechur A2 Milk

November 27, 2017 By arne hendriks Off

The Incredible Shrinking Man is not big on dairy because it promotes excess growth in the body. But we’ll make an exception for the milk of the tiny Vechur cow originating from the warm and humid climate of the state of Kerala in southern India. According…

Long Legged Risk

October 3, 2016 By arne hendriks 0

Long legs beautiful? Perhaps, but according to a study presented at the American Association for Cancer Research’s annual meeting  the long-legged have a 42 percent higher risk of developing bowel cancer. Lead author of the study Guillaume Onyeaghala has two hypotheses that may explain the…

Full Length over Exon Deficient

November 14, 2015 By arne hendriks 0

The growth hormone receptor is embedded in the outer membrane of the cell. It has three major parts: 1. An extracellular region that sticks out from the surface of the cell. 2. A transmembrane region that anchors the receptor to the cell membrane. 3. An…

Growth Antagonists: Delta Cells

August 13, 2013 By arne hendriks 1

The growth of the human body is a highly complex process with many growth agonists and -antagonists taking centre stage at different times. In Growth Antagonists we each time zoom in on one of the key players as we’re trying to understand the puzzle of…

Ituri Zebras (Mbuti)

May 12, 2013 By arne hendriks 0

At an adult height of only 135-140 centimeters the Mbuti of Congo are about 25 to 30% shorter than an average person and among the shortest people alive today. Their average weight of only 40 kg constitutes a significantly more intelligent and efficient body design, needing…

Pegvisomant

November 19, 2012 By arne hendriks 1

Pegvisomant (tradename Somavert) is a genetically engineered analogue of the human growth hormone (GH) that stops unnaturally vigorous growth in patients with acromegaly. It works as a GH receptor antagonist and blocks or dampens agonist-mediated responses by binding to growth hormone receptors on cell surfaces. Pegvisomant is used…

GH Resistance

December 26, 2011 By arne hendriks 1

Stature is a highly heritable trait controlled by genetic and environmental factors. Pygmies display a remarkable and inspiring resistance to growth hormone (GH). African Pygmies represent a paradigmatic example of non-disease-related idiopathic short stature. Even if large quantities of GH are administered to them, they simply ignore…

The Larons

November 9, 2011 By arne hendriks 2

People living in remote villages in Ecuador have a genetic mutation that may just hold the key to shrinking mankind. The villagers have a rare condition known as Laron syndrome. They are generally less than three and a half feet tall, they are proportional, and interestingly, they are…

Milk

October 17, 2011 By arne hendriks 1

Body height is a classic polygenic trait. About 80% to 90% of your height is inherited and 10% to 20% owed to environmental factors, of which nutrition is the most important. Of those nutrients perhaps milk is the one associated most with increased human height.…

Small & Smart

January 29, 2011 By arne hendriks 1

There is an understandable fear that in shrinking the human body we might lose part of our brain capacity. With a projected head size of about 6 x 4,5cm it’s an obvious concern. One of the possible solutions we’ve reported on in a previous post,…

The Methuselah Gene

September 28, 2010 By arne hendriks 3

The strong correlation between size and the aging process has been discussed here before. However the connection between the two is a very complex puzzle of different ingredients, all playing a role in the aging/growing process. A type of gene mutation long known to extend…